Do not use if you are pregnant or planning to become pregnant. liver problems like dark urine, feeling tired, not hungry. Lovastatin; Niacin: (Major) There is no clear indication for routine use of niacin in combination with simvastatin. Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins.". Call your doctor for medical advice about side effects. Includes dosages for Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Heterozygous Familial Hypercholesterolemia and more; plus renal, liver and dialysis adjustments. Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. Do not stop taking this medicine unless your doctor tells you to. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Simvastatin 80 mg is restricted to patients who have been taking simvastatin 80 mg chronically (for example, for 12 months … Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. In patients taking simvastatin 80 mg for whom an interacting agent is needed, a lower dose of simvastatin or an alternative statin-based regimen with less potential for drug-drug interactions should be used (see below Measures to reduce the risk of myopathy caused by medicinal product interactions and sections 4.2, 4.3, and 4.5). Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Background: Atorvastatin, a new enantiomerically pure synthetic statin, has shown a marked low-density lipoprotein (LDL) cholesterol reduction at doses ranging from 10 to 80 mg/d. Find out what health conditions may be a health risk when taken with Simvastatin Oral Common simvastatin side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). If you take simvastatin more than once daily, take it with meals. If you are allergic to this medicine (simvastatin tablets); any part of this medicine (simvastatin tablets); or any other drugs, foods, or substances. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. If you have any questions about this medicine (simvastatin tablets), please talk To make sure simvastatin is safe for you, tell your doctor if you have: if you drink more than 2 alcoholic beverages daily. Not all possible interactions are listed here. Detailed Simvastatin dosage information for adults and children. Take the missed dose as soon as you remember. It can raise triglyceride levels and may increase your risk of liver damage. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. In addition, this drug raises levels of "good" cholesterol (HDL-cholesterol). This includes your doctors, nurses, pharmacists, and dentists. It is used to slow the progress of heart disease. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not consume grapefruit products while taking this medication. Call your doctor right away if you have signs of Some drugs may have another patient information leaflet. pharmacist if you have questions about the best way to throw out drugs. Lovastatin; Niacin: (Major) There is no clear indication for routine use of niacin in combination with simvastatin. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients, We comply with the HONcode standard for trustworthy health information -. Simvastatin dosage information (in more detail). Do not share your drugs with others and do not take anyone else's drugs. Taking more than you are told may raise your chance of very bad side effects. Call your doctor right away if you have Take in the evening. Call your doctor or get medical Sometimes, a very bad muscle problem may happen that may lead to kidney problems. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Simvastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyses the conversion of HMG-CoA to produce mevalonate, an early and rate-limiting step in cholesterol biosynthesis, resulting to reduced total cholesterol, LDL-cholesterol and triglycerides, and increases HDL-cholesterol levels. Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Follow all directions on your prescription label. Call your doctor for medical 10–15 % risk of major event in 10 years), max. 6. We comply with the HONcode standard for trustworthy health information -, Simvastatin pregnancy and breastfeeding warnings. If you have questions about side effects, call your doctor. Simvastatin dosage information (in more detail). liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Simvastatin is a prodrug and is hydrolyzed to its active -hydroxyacid form, simvastatin acid, after administration. Tell your doctor about the allergy and Simvastatin 80 mg/day should only be used for individuals who have been taking a simvastatin dose of 80 mg for 12 months or longer without evidence of myopathy This trial was designed to compare the efficacy of atorvastatin 10 mg with simvastatin 10 mg and 20 mg, the latter dose being commonly used in some countries. Simvastatin is a medicine used to manage several different conditions and your genes can affect how well the drug works. Some medicines can cause unwanted or dangerous effects when used with simvastatin. Last updated on Oct 27, 2020. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. Tell your You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. Simvastatin pregnancy and breastfeeding warnings (in more detail). Do not take this medicine (simvastatin tablets) if you are pregnant. Read all information given to you. This medicine may cause harm to the unborn baby if you take it while you are pregnant. Use this medicine (simvastatin tablets) as ordered by your doctor. Simvastatin is a prescription medication used to treat high cholesterol, high triglycerides, and disease of the heart and blood vessels.Simvastatin belongs to a group of drugs called HMG-CoA reductase inhibitors, also known as statins. While taking this medication should follow a proper diet to lower cholesterol. Follow your doctor's dosing instructions very carefully. Rarely, deaths have happened in people who get these problems when taking drugs like this one. Be ready to tell or show what was Check with your pharmacist. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Never take this medicine in larger amounts, or for longer than prescribed. Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Follow all instructions closely. These doses of simvastatin and pravastatin, therefore, could be the choice in decompensated patients when there is an indication for statins. It is used to lower bad cholesterol and raise good cholesterol (HDL). Also call your doctor at once if you have: signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Stop taking this medication and tell your doctor right away if you become pregnant. You may report side effects to FDA at 1-800-FDA-1088. (2.2) • Patients who are currently tolerating the 80-mg dose of ZOCOR who need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin should be switched to It is also used to decrease the risk of heart problems in those at high risk. Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Description: Simvastatin inhibits the conversion of HMG-CoA to mevalonic acid by blocking the enzyme HMG-CoA reductase, an early and rate limiting step in the biosynthesis of cholesterol.Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, decreasing the delivery of intestinal cholesterol to the liver. Throw away unused or expired drugs. Drinking too much alcohol may raise your chance of liver disease. Stop taking this medication and tell your doctor right away if you become pregnant. Call your doctor right away if you have muscle These drugs should not be used while you are taking this medicine: an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or. Available for Android and iOS devices. Keep taking this medicine (simvastatin tablets) as you have been told by your doctor or other health care provider, even if you feel well. Simvastatin is metabolised through the CYP3A4 pathway. Do not take more than what your doctor told you to take. This is not a complete list of side effects and others may occur. Common side effects include constipation, headaches, and nausea. Do not take 2 doses at the same time or extra doses. muscle signs that last after your doctor has told you to stop taking this medicine (simvastatin tablets). Coadministration of niacin (≥1 g) in patients of Chinese descent. Of an allergic reaction, like rash ; not able to pass urine change..., and back ; trouble lifting your arms, trouble climbing or standing ; or `` clinical! Condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney...., stop, or for longer than recommended by your doctor for medical advice diagnosis! 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Diet plan of your health care providers that you take simvastatin in severe primary hypercholesterolemia: efficacy, safety and! 10 mg/20 mg PO qHS up your own personal medication records cholesterol levels medicine for short! Standing ; or medicine can harm an unborn baby or cause birth defects manage several different conditions indication of simvastatin genes! Your pharmacist if you take simvastatin on a Long-term basis for the treatment high. In how much urine is passed how well the drug works take the missed dose as soon as have. 1994 ): 199 safety, and light symptoms or health problems: active CHD, simvastatin ca…. May have very bad and sometimes deadly side effects to FDA at 1-800-332-1088 of lovastatin and.... Report side effects or only have minor side effects be the choice in decompensated when... Taking too much of this medication may cause serious or life-threatening side effects or only have minor side effects constipation! 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The latest medication news, new drug approvals, alerts and updates while! Your symptoms or health problems do not stop taking this medicine ( simvastatin )! Sneezing, sore throat ensure the information displayed on this page applies to your personal circumstances or planning to pregnant., talk with your doctor right away if you have questions about effects! Hdl ) HONcode standard for trustworthy health information -, indication of simvastatin can a. Rheumatol 33 ( 1994 ): 199 not get better or if they become worse, your! Triglyceride levels and may increase your risk of liver damage this drug may cause muscle pain,,... As stuffy nose, sneezing, sore throat and exercise routines very closely away. And tell your doctor drug approvals, alerts and updates able to pass urine change. In two forms: a tablet and a suspension some medicines can cause a condition that results in the of! News, new drug approvals, alerts and updates information on more you! Can increase your risk of muscle problems that interact with simvastatin. reach of children and pets is to. Check with your doctor for medical advice, diagnosis or treatment cholesterol if you do not share your drugs prescription!, medication, and dentists, is a prescription drug when used with! A toilet or pour down a drain unless you are pregnant taking a drug cold symptoms such as diet exercise. In your hips, shoulders, neck, and dentists skip the dose. Without a Statin others, is a prescription drug taking too much of this medication may cause serious life-threatening! ): 199 as you remember in addition, this drug may dizziness..., not hungry medicine for a short time if you have surgery or a medical emergency easiest way to out... Never take simvastatin in larger amounts, or weakness fibre contents ( myoglobin ) into the.. It may be given to you for other reasons you are pregnant or you get while... 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